Journal article

HISTOLOGICAL EXAMINATION OF ONCHOCERCOMATA AFTER THERAPY WITH IVERMECTIN

EJ ALBIEZ, G WALTER, A KAISER, P RANQUE, HS NEWLAND, AT WHITE, BM GREENE, HR TAYLOR, DW BUTTNER

TROPICAL MEDICINE AND PARASITOLOGY | GEORG THIEME VERLAG | Published : 1988

Abstract

During chemotherapy trials in hyperendemic onchocerciasis areas in West Africa 15 adult nodule carriers in Liberia and 24 patients in Mali received single doses of ivermectin (150 or 200 micrograms/kg). Nodules were extirpated two, six and ten months after therapy and examined histologically. No macrofilaricidal effect of ivermectin was observed. Two months after therapy, in 93% of all female worms with intrauterine stretched microfilariae nearly all microfilariae were degenerated. The percentage was lower after ten months but still significantly higher than in untreated control groups. Ivermectin did not cause degeneration of the intrauterine coiled microfilariae. But the percentage of the ..

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