Journal article

TREATMENT OF ONCHOCERCIASIS - THE OCULAR EFFECTS OF IVERMECTIN AND DIETHYLCARBAMAZINE

HR TAYLOR, RP MURPHY, HS NEWLAND, AT WHITE, SA DANNA, E KEYVANLARIJANI, MA AZIZ, EW CUPP, BM GREENE

JAMA Ophthalmology | AMER MEDICAL ASSOC | Published : 1986

Abstract

The ocular changes that occur with diethylcarbamazine treatment of onchocerciasis seriously restrict its usefulness. Ivermectin, a newly developed antifilarial drug, was compared with diethylcarbamazine for treatment of onchocerciasis in a double-masked, placebo-controlled trial. Thirty men with moderate to severe infection and ocular involvement were randomly assigned to receive ivermectin as a single oral dose (200 micrograms/kg), diethylcarbamazine (administered for eight days), or placebo. Detailed ocular examinations were performed serially over a 12-month period. Diethylcarbamazine treatment caused a marked increase in living and dead microfilariae in the cornea, punctate opacities, an..

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