Ocular and systemic complications of diethylcarbamazine therapy for onchocerciasis: Association with circulating immune complexes

Abstract

Diethylcarbamazine (DEC) therapy for Onchocerca volvulus infection results in frequent ocular and systemic complications, but the pathogenesis of these complications is unclear. Twenty men with O. volvulus infection were treated over a period of six months with DEC given daily for one week and weekly thereafter. Major systemic and ocular complications included proteinuria, severe pruritis, visual field constriction, optic nerve pallor, chorioretinitis, anterior uveitis, and punctate keratitis. Level of circulating immune complexes (CICs) were increased (>11% [125I]C1q binding) in 14 of the 20 men prior to treatment. Persons with pretreatment C1q binding activity of >30% were at increased ris..