Journal article

Improved Diagnosis of Prosthetic Joint Infection by Culturing Periprosthetic Tissue Specimens in Blood Culture Bottles

Trisha N Peel, Brenda L Dylla, John G Hughes, David T Lynch, Kerryl E Greenwood-Quaintance, Allen C Cheng, Jayawant N Mandrekar, Robin Patel

mBio | AMER SOC MICROBIOLOGY | Published : 2016

Abstract

UNLABELLED: Despite known low sensitivity, culture of periprosthetic tissue specimens on agars and in broths is routine. Culture of periprosthetic tissue samples in blood culture bottles (BCBs) is potentially more convenient, but it has been evaluated in a limited way and has not been widely adopted. The aim of this study was to compare the sensitivity and specificity of inoculation of periprosthetic tissue specimens into blood culture bottles with standard agar and thioglycolate broth culture, applying Bayesian latent class modeling (LCM) in addition to applying the Infectious Diseases Society of America (IDSA) criteria for prosthetic joint infection. This prospective cohort study was condu..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council


Awarded by National Institutes of Health


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES


Funding Acknowledgements

Trisha Peel was supported by the Richard Memorial Kemp Fellowship, Royal Australasian College of Physicians, and the National Health and Medical Research Council Medical Early Career fellowship (APP1069734). Allen Cheng was supported by a National Health and Medical Research Council Career Development Fellowship 2 (APP1068732). Robin Patel was supported by the National Institutes of Health (R01 AR056647 and R01 AI91594).