RESPONSES OF POPLITEAL LYMPH-NODE OF SHEEP TO ROSS RIVER AND KUNJIN VIRUSES

Abstract

SummaryThe responses of popliteal lymph nodes of sheep to Ross River virus (RRV) or Kunjin virus (KV) have been studied by monitoring the cell populations, virus titre. antibody titre and plaque‐forming cell (PFC) content of the efferent lymph. In a typical primary response to subcutaneous inoculation in the lower hint! limb of either RRV or KV, the flow rate of lymph increased slightly. Increased cell concentrations in the lymph following inoculation caused the hourly cell outputs to rise 5·3‐ to 10·1‐fold above pre‐challenge levels. High cell outputs were sustained at greater than 3‐fold above pre‐challenge figures for up to 10 days. The increased number of large, blastic lymphocytes range..