Journal article
EFFECT OF AN IRON-CHELATING AGENT ON LYMPHOCYTE-PROLIFERATION
N BOWERN, IA RAMSHAW, P BADENOCHJONES, PC DOHERTY
AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE | AUST JRNL EXP BIOL & MED SCI | Published : 1984
DOI: 10.1038/icb.1984.70
Abstract
SummaryThe effect of the iron‐chelating: agent desferrioxamine on lymphocyte proliferation has been studied. Desferrioxamine at concentrations of 15 μM totally inhibited the proliferation of Concanavalin A‐stimulated lymphocytes, whereas iron‐saturated desferrioxamine was ineffective. Other metal salts, however, had little or no effect on the inhibition induced by this drug. Desferrioxamine was more effective at suppressing proliferation of T lymphocytes than B lymphocytes and additionally suppressed mixed lymphocyte cultures and the generation of cytotoxic T cells.