Journal article

Cytokine expression in murine cytomegalovirus-induced myocarditis: modulation with interferon-alpha therapy

JC Lenzo, JP Mansfield, S Sivamoorthy, VS Cull, CM James

Cellular Immunology | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2003


Cytomegalovirus-induced myocarditis is largely immune-mediated. BALB/c mice produced higher levels of IL-4 in the heart indicative of a Th2-like response. Although IL-6, IL-10, IL-18, and TNF-alpha were produced in the heart during acute infection, BALB/c mice lacked a substantial IL-2 and IFN-gamma response. Conversely, C57BL/6 mice produced significant levels of IFN-gamma in the heart with no significant levels of IL-4 or IL-6, suggestive of a dominant Th1-like response to virus infection. IFN-alpha/beta immunotherapy is known to suppress the development of MCMV-myocarditis. Cytokine secretion in IFN-stimulated MCMV-infected BALB/c myocytes was found to be IFN subtype-dependent with elevat..

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University of Melbourne Researchers