Journal article

Expression and localization of COX-2 in human airways and cultured airway epithelial cells

DN Watkins, DJ Peroni, JC Lenzo, DA Knight, MJ Garlepp, PJ Thompson

European Respiratory Journal | MUNKSGAARD INT PUBL LTD | Published : 1999


Cyclo-oxygenase is the rate-limiting enzyme in the prostanoid pathway. Although expression of the inducible isoform of cyclo-oxygenase (COX-2) is associated with cytokine-mediated inflammation, recent evidence suggests a homeostatic role for epithelial COX-2 in the gastrointestinal tract. The aim of this study was to examine the expression and localization of COX-2 in human airway epithelium both in vivo and in vitro. Human airway specimens from patients undergoing lung resection surgery for primary lung tumours (n=10) or nasal mucosal resection for non-inflammatory nasal obstruction (n=5) were examined for COX-2 expression by in situ hybridization and immunohistochemistry. COX-2 expression ..

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