Journal article

Expression and localization of cyclo-oxygenase isoforms in non-small cell lung cancer

DN Watkins, JC Lenzo, A Segal, MJ Garlepp, PJ Thompson

European Respiratory Journal | MUNKSGAARD INT PUBL LTD | Published : 1999


The beneficial effects of cyclo-oxygenase (COX) inhibitors in both colon cancer and adenomatous polyps suggest a role for the prostanoid pathway in epithelial malignancy. Although variable prostanoid synthesis in non-small cell lung cancer (NSCLC) has been demonstrated in freshly obtained tissue, COX messenger ribonucleic acid (mRNA) and protein localization in such tumours had not been investigated ex vivo. Thirty-four cases of primary NSCLC were examined for both constitutive (COX-1) and inducible COX (COX-2) by means of in situ hybridization and immunohistochemistry. COX-1 mRNA expression was absent or below the level of detection via in situ hybridization. COX-1 immunohistochemistry demo..

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University of Melbourne Researchers