Journal article

Type I IFN-beta gene therapy suppresses cardiac CD8( ) T-cell infiltration during autoimmune myocarditis

EJ Bartlett, JC Lenzo, S Sivamoorthy, JP Mansfield, VS Cull, CM James

Immunology and Cell Biology | WILEY | Published : 2004


Gene therapy using DNA encoding type I IFN subtypes IFNA6, IFNA9 and IFNB suppresses murine cytomegalovirus (MCMV)-myocarditis, a predominantly cell-mediated disease in BALB/c mice. CD8(+) T cells are the principal cell type within the inflamed myocardium. As such, we investigated the effects of IFN subtype treatment on this T-cell subset and other cell types in the cardiac infiltrate. In the acute phase of disease, IFNA6 and IFNA9 treatments significantly reduced the number of CD8(+) T cells within the foci of cellular infiltration in the heart. During the chronic phase, which is primarily autoimmune in nature, IFNB treatment significantly reduced CD8(+) T cells. B-cell and neutrophil numbe..

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University of Melbourne Researchers