Journal article
A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
AM Scott, G Wiseman, S Welt, A Adjei, FT Lee, W Hopkins, CR Divgi, LH Hanson, P Mitchell, DN Gansen, SM Larson, JN Ingle, EW Hoffman, P Tanswell, G Ritter, LS Cohen, P Bette, L Arvay, A Amelsberg, D Vlock Show all
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2003
Abstract
Purpose: The purpose of this research was to determine the safety, immunogenicity, pharmacokinetics, biodistribution, and tumor uptake of repeat infusions of a complementarity-determining region grafted humanized antibody (sibrotuzumab) directed against human fibroblast activation protein (FAP). Experimental Design: A Phase I open-label dose escalation study was conducted in patients with cancers epidemiologically known to be FAP positive. Patients were entered into one of four dosage tiers of 5, 10, 25, or 50 mg/m2 sibrotuzumab, administered weekly for 12 weeks, with trace labeling with 8-10 mCi of 131I in weeks 1, 5, and 9. Results: A total of 26 patients were entered into the trial (15 ma..
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