Comparison and evaluation of PET/CT image registration

Abstract

Diagnosis, treatment planning and prognosis may be improved by combining functional data with anatomic location via PET/CT dual-modality image registration. The aim of this work is to reveal the spatial accuracy, reliability and speed of registration techniques used in Gemini™ PET/CT Imaging System, as a part of quality assurance program for clinical and research applications. A multi-layer alignment bearing source device was used to validate PET/CT intrinsic alignment, as well as a Rando® Man phantom. A series of known transformations were performed to simulate different misalignment between PET and CT images. Two semi-automated registration techniques used to correct misalignment were asse..