Journal article
Dynamics of HCV RNA Levels During Acute Hepatitis C Virus Infection
B Hajarizadeh, J Grebely, T Applegate, GV Matthews, J Amin, K Petoumenos, M Hellard, W Rawlinson, A Lloyd, J Kaldor, GJ Dore
Journal of Medical Virology | WILEY | Published : 2014
DOI: 10.1002/jmv.24010
Abstract
Understanding viral dynamics during acute hepatitis C virus (HCV) infection can provide important insights into immunopathogenesis and guide early treatment. The aim of this study was to investigate the dynamics of HCV RNA and alanine transaminase (ALT) levels during recent HCV infection in the Australian Trial in Acute Hepatitis C (ATAHC). ATAHC was a prospective study of the natural history of recently acquired HCV infection. Longitudinal HCV RNA and ALT levels were compared among individuals with persistent infection and spontaneous clearance. Among those with HCV persistence (n = 104) and HCV clearance (n = 30), median HCV RNA (5.2 vs. 4.1 log IU/ml, respectively) and ALT levels (779 vs...
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Awarded by National Institute on Drug Abuse
Funding Acknowledgements
Grant sponsor: National Institutes of Health; Grant number: RO1 DA 15999-01.; Grant sponsor: Australian Government, Department of Health and Ageing; Grant sponsor: Roche Pharmaceuticals; Grant sponsor: Australian Postgraduate Award; Grant sponsor: National Health and Medical Research Council Career Development Fellowships; Grant sponsor: National Health and Medical Research Council Practitioner Research Fellowships; Grant sponsor: VicHealth Senior Research Fellowship; Grant sponsor: National Health and Medical Research Council Research Fellowships