Journal article
Maintenance of Th1 hepatitis C virus (HCV)-specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment
JK Flynn, GJ Dore, M Hellard, B Yeung, WD Rawlinson, PA White, JM Kaldor, AR Lloyd, RA Ffrench
Journal of Gastroenterology and Hepatology Australia | WILEY | Published : 2013
DOI: 10.1111/jgh.12265
Abstract
Background and Aim: T-cell responses against hepatitis C are believed to be critical in achieving both natural and treatment-induced clearance. However, rapid clearance of antigen with early treatment of primary infection may result in reduced or poorly sustained cellular immunity. This study longitudinally examined Th1 and Th2 hepatitis C virus (HCV)-specific cytokine production and T-cell effector function from subjects enrolled in the Australian Trial in Acute Hepatitis C comparing three groups: treatment-induced clearance (sustained virological response [SVR]), treatment non-response, and untreated spontaneous clearance. Methods: HCV-specific T-cell responses were characterized by HCV pe..
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Awarded by National Institute on Drug Abuse
Funding Acknowledgements
This paper was funded by the National Institutes of Health grant R01 DA15999 and the Australian Government Department of Health and Ageing. The views expressed in this publication do not necessarily represent the position of the Australian Government. The Kirby Institute is affiliated with the Faculty of Medicine, University of New South Wales. Roche Pharmaceuticals supplied financial support for pegylated IFN-alfa-2a/ribavirin. The authors gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program received by the Burnet Institute.