Journal article

Temporal transcriptional response to latency reversing agents identifies specific factors regulating HIV-1 viral transcriptional switch.

Narasimhan J Venkatachari, Jennifer M Zerbato, Siddhartha Jain, Allison E Mancini, Ansuman Chattopadhyay, Nicolas Sluis-Cremer, Ziv Bar-Joseph, Velpandi Ayyavoo

Retrovirology | Published : 2015

Abstract

BACKGROUND: Latent HIV-1 reservoirs are identified as one of the major challenges to achieve HIV-1 cure. Currently available strategies are associated with wide variability in outcomes both in patients and CD4(+) T cell models. This underlines the critical need to develop innovative strategies to predict and recognize ways that could result in better reactivation and eventual elimination of latent HIV-1 reservoirs. RESULTS AND DISCUSSION: In this study, we combined genome wide transcriptome datasets post activation with Systems Biology approach (Signaling and Dynamic Regulatory Events Miner, SDREM analyses) to reconstruct a dynamic signaling and regulatory network involved in reactivation me..

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University of Melbourne Researchers