Journal article
In vitro studies show that sequence variability contributes to marked variation in hepatitis B virus replication, protein expression, and function observed across genotypes
V Sozzi, R Walsh, M Littlejohn, D Colledge, K Jackson, N Warner, L Yuen, SA Locarnini, PA Revill
Journal of Virology | AMER SOC MICROBIOLOGY | Published : 2016
DOI: 10.1128/JVI.01293-16
Abstract
The hepatitis B virus (HBV) exists as 9 major genotypes (A to I), one minor strain (designated J) and multiple subtypes. Marked differences in HBV natural history, disease progression and treatment response are exhibited by many of these genotypes and subtypes. For example, HBV genotype C is associated with later hepatitis B e antigen (HBeAg) seroconversion and high rates of liver cancer compared to other HBV genotypes, whereas genotype A2 is rarely associated with HBeAg-negative disease or liver cancer. The reasons for these and other differences in HBV natural history are yet to be determined but could in part be due to sequence differences in the HBV genome that alter replicative capacity..
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Awarded by Department of Health \ National Health and Medical Research Council (NHMRC)
Funding Acknowledgements
This work, including the efforts of Peter A. Revill, was funded by Keir Reseach Fellowship, Royal Melbourne Hospital. This work, including the efforts of Nadia Warner, was funded by Department of Health vertical bar National Health and Medical Research Council (NHMRC) (APP1065476).