GWAlpha: genome-wide estimation of additive effects (alpha) based on trait quantile distribution from pool-sequencing experiments
Alexandre Fournier-Level, Charles Robin, David J Balding
Bioinformatics | Oxford University Press (OUP) | Published : 2017
Motivation Sequencing pools of individuals (Pool-Seq) is a cost-effective way to gain insight into the genetics of complex traits, but as yet no parametric method has been developed to both test for genetic effects and estimate their magnitude. Here, we propose GWAlpha, a flexible method to obtain parametric estimates of genetic effects genome-wide from Pool-Seq experiments. Results We showed that GWAlpha powerfully replicates the results of Genome-Wide Association Studies (GWAS) from model organisms. We perform simulation studies that illustrate the effect on power of sample size and number of pools and test the method on different experimental data. Availability and Implementation GWAlph..View full abstract
Awarded by Human Frontier in Science Program Long-Term fellowship
Work funded by a Human Frontier in Science Program Long-Term fellowship (LT000907/2012-L) to AFL.