Neuropathology of early HIV-1 infection.
F Gray, F Scaravilli, I Everall, F Chretien, S An, D Boche, H Adle-Biassette, L Wingertsmann, M Durigon, B Hurtrel, F Chiodi, J Bell, P Lantos
Brain Pathology | Published : 1996
Early HIV-1 invasion of the central nervous system has been demonstrated by many cerebrospinal fluid studies; however, most HIV-1 carriers remain neurologically unimpaired during the so called "asymptomatic" period lasting from seroconversion to symptomatic AIDS. Therefore, neuropathological studies in the early pre-AIDS stages are very few, and the natural history of central nervous system changes in HIV-1 infection remains poorly understood. Examination of brains of asymptomatic HIV-1 positive individuals who died accidentally and of rare cases with acute fatal encephalopathy revealing HIV infection, and comparison with experimental simian immunodeficiency virus and feline immunodeficiency..View full abstract