Distinct Brainstem and Forebrain Circuits Receiving Tracheal Sensory Neuron Inputs Revealed Using a Novel Conditional Anterograde Transsynaptic Viral Tracing System
Alice E McGovern, Alexandria K Driessen, David G Simmons, Joseph Powell, Nicholas Davis-Poynter, Michael J Farrell, Stuart B Mazzone
JOURNAL OF NEUROSCIENCE | SOC NEUROSCIENCE | Published : 2015
Sensory nerves innervating the mucosa of the airways monitor the local environment for the presence of irritant stimuli and, when activated, provide input to the nucleus of the solitary tract (Sol) and paratrigeminal nucleus (Pa5) in the medulla to drive a variety of protective behaviors. Accompanying these behaviors are perceivable sensations that, particularly for stimuli in the proximal end of the airways, can be discrete and localizable. Airway sensations likely reflect the ascending airway sensory circuitry relayed via the Sol and Pa5, which terminates broadly throughout the CNS. However, the relative contribution of the Sol and Pa5 to these ascending pathways is not known. In the prese..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia (Grants 1042528, 1025589, and 1078943 to S.B.M. and M.J.F.). We thank Lynn Enquist and Halina Staniszewska Goraczniak (Princeton University, Princeton, NJ) for their generosity in supplying the original wild-type H129 strain of HSV-1.