Journal article

Metabolomic biomarkers predictive of early structural lung disease in cystic fibrosis

Charles R Esther, Lidija Turkovic, Tim Rosenow, Marianne S Muhlebach, Richard C Boucher, Sarath Ranganathan, Stephen M Stick

European Respiratory Journal | EUROPEAN RESPIRATORY SOC JOURNALS LTD | Published : 2016

Abstract

Neutrophilic airway inflammation plays a role in early structural lung disease in cystic fibrosis, but the mechanisms underlying this pathway are incompletely understood.Metabolites associated with neutrophilic inflammation were identified by discovery metabolomics on bronchoalveolar lavage fluid supernatant from 20 preschool children (2.9±1.3 years) with cystic fibrosis. Targeted mass-spectrometric detection of relevant metabolites was then applied to 34 children (3.5±1.5 years) enrolled in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) who underwent chest computed tomography and bronchoalveolar lavage from two separate lobes during 42 visits. Relationship..

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Grants

Awarded by NIH/NHLBI


Awarded by NC TraCS


Awarded by NIH/NIEHS


Awarded by NHMRC


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES


Funding Acknowledgements

C.R. Esther Jr, L. Turkovic, M.S. Muhlebach, and S.M. Stick were supported by NIH/NHLBI R01-HL116228. C.R. Esther Jr was also supported by NC TraCS 50KR51009, NIH/NIEHS P30-ES10126, and NIH/NHLBI K23-HL089708. L. Turkovic, T. Rosenow and S.M. Stick were supported by NHMRC GNT1000896. R.C. Boucher was supported by NIH/NHLBI HL34322, HL107168, P01-HL08808, P30-DK065988, P01-HL110873, and P50-HL107168. Funding information for this article has been deposited with the Open Funder Registry.