Journal article

The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants

Flora S Kano, Flavia A Souza-Silva, Leticia M Torres, Barbara AS Lima, Tais N Sousa, Jessica RS Alves, Roberto S Rocha, Cor JF Fontes, Bruno AM Sanchez, John H Adams, Cristiana FA Brito, Douglas EV Pires, David B Ascher, Ana Maria Sell, Luzia H Carvalho



BACKGROUND: The human malaria parasite Plasmodium vivax infects red blood cells through a key pathway that requires interaction between Duffy binding protein II (DBPII) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). A high proportion of P. vivax-exposed individuals fail to develop antibodies that inhibit DBPII-DARC interaction, and genetic factors that modulate this humoral immune response are poorly characterized. Here, we investigate if DBPII responsiveness could be HLA class II-linked. METHODOLOGY/PRINCIPAL FINDINGS: A community-based open cohort study was carried out in an agricultural settlement of the Brazilian Amazon, in which 336 unrelated volunt..

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Awarded by Research Foundation of Minas Gerais (FAPEMIG)

Awarded by MRC

Funding Acknowledgements

This work was supported by The National Council for Scientific and Technological Development (CNPq); The Research Foundation of Minas Gerais (FAPEMIG); PAPES VI/CNPq/FIOCRUZ; LHC is a research fellow from CNPq. LMT, BASL, and JRSA are supported by the Coordination for the Improvement of Higher Education Personnel (CAPES). DBA and DEVP are supported by a Newton Fund RCUK-CONFAP Grant awarded by The Medical Research Council (MRC) and The Research Foundation of Minas Gerais (FAPEMIG) (MR/M026302/1). DBA is an NHMRC CJ Martin Fellow (APP1072476). DEVP is supported by the Rene Rachou Research Center (CPqRR/FIOCRUZ Minas), Brazil. The funders had no role in study design, data analysis, decision to publish, or preparation of the manuscript.