The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants

Flora S Kano; Flavia A Souza-Silva; Leticia M Torres; Barbara AS Lima; Tais N Sousa; Jessica RS Alves; Roberto S Rocha; Cor JF Fontes; Bruno AM Sanchez; John H Adams; Cristiana FA Brito; Douglas EV Pires; David B Ascher; Ana Maria Sell; Luzia H Carvalho

Journal article

The Presence, Persistence and Functional Properties of Plasmodium vivax Duffy Binding Protein II Antibodies Are Influenced by HLA Class II Allelic Variants

Flora S Kano, Flavia A Souza-Silva, Leticia M Torres, Barbara AS Lima, Tais N Sousa, Jessica RS Alves, Roberto S Rocha, Cor JF Fontes, Bruno AM Sanchez, John H Adams, Cristiana FA Brito, Douglas EV Pires, David B Ascher, Ana Maria Sell, Luzia H Carvalho

PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2016

DOI: 10.1371/journal.pntd.0005177

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Abstract

BACKGROUND: The human malaria parasite Plasmodium vivax infects red blood cells through a key pathway that requires interaction between Duffy binding protein II (DBPII) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). A high proportion of P. vivax-exposed individuals fail to develop antibodies that inhibit DBPII-DARC interaction, and genetic factors that modulate this humoral immune response are poorly characterized. Here, we investigate if DBPII responsiveness could be HLA class II-linked. METHODOLOGY/PRINCIPAL FINDINGS: A community-based open cohort study was carried out in an agricultural settlement of the Brazilian Amazon, in which 336 unrelated volunt..

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University of Melbourne Researchers

Douglas Valente Pires Author Computing and Information Systems

David Ascher Author Baker Department of Cardiometabolic Health

Grants

Awarded by Research Foundation of Minas Gerais (FAPEMIG)

Awarded by MRC

Funding Acknowledgements

This work was supported by The National Council for Scientific and Technological Development (CNPq); The Research Foundation of Minas Gerais (FAPEMIG); PAPES VI/CNPq/FIOCRUZ; LHC is a research fellow from CNPq. LMT, BASL, and JRSA are supported by the Coordination for the Improvement of Higher Education Personnel (CAPES). DBA and DEVP are supported by a Newton Fund RCUK-CONFAP Grant awarded by The Medical Research Council (MRC) and The Research Foundation of Minas Gerais (FAPEMIG) (MR/M026302/1). DBA is an NHMRC CJ Martin Fellow (APP1072476). DEVP is supported by the Rene Rachou Research Center (CPqRR/FIOCRUZ Minas), Brazil. The funders had no role in study design, data analysis, decision to publish, or preparation of the manuscript.