Journal article
Immunometabolic dysregulation is associated with reduced cortical thickness of the anterior cingulate cortex
LS van Velzen, L Schmaal, Y Milaneschi, MJ van Tol, NJA van der Wee, DJ Veltman, BWJH Penninx
Brain Behavior and Immunity | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2017
Abstract
Background Immunometabolic dysregulation (low-grade inflammation and metabolic dysregulation) has been associated with the onset and more severe course of multiple psychiatric disorders, partly due to neuroanatomical changes and impaired neuroplasticity. We examined the effect of multiple markers of immunometabolic dysregulation on hippocampal and amygdala volume and anterior cingulate cortex thickness in a large sample of patients with depression and/or anxiety and healthy subjects (N = 283). Methods Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-a), c-reactive protein (CRP), triglyceride levels and HDL-cholesterol and genomic profile risk scores (GPRS) for immunometabolic dysregula..
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Awarded by Institute of Neurosciences, Mental Health and Addiction
Funding Acknowledgements
This work was supported by the Geestkracht program of the Netherlands Organization for Health Research and Development (Zon-Mw, Grant No. 10-000-1002) and is also supported by participating universities and mental health care organizations (VU University Medical Center, GGZ inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Institute for Quality of Health Care (IQ Healthcare), Netherlands Institute for Health Services Research (NIVEL) and Netherlands Institute of Mental Health and Addiction (Trimbos). LvV, LS and BWJHP are supported by NWO VICI grant (number 91811602). LS is supported by The Netherlands Brain Foundation Grant No. (F2014(1)-24). MJvT is supported by NWO VENI grant (number 016.156.077)