Journal article

ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

Paul M Thompson, Ole A Andreassen, Alejandro Arias-Vasquez, Carrie E Bearden, Premika S Boedhoe, Rachel M Brouwer, Randy L Buckner, Jan K Buitelaar, Kazima B Bulayeva, Dara M Cannon, Ronald A Cohen, Patricia J Conrod, Anders M Dale, Ian J Deary, Emily L Dennis, Marcel A de Reus, Sylvane Desrivieres, Danai Dima, Gary Donohoe, Simon E Fisher Show all

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2017

Abstract

In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia includ..

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Awarded by NIH Institutes


Awarded by Biotechnology and Biological Sciences Research Council


Awarded by Medical Research Council


Awarded by Wellcome Trust


Awarded by BBSRC


Awarded by MRC


Awarded by NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES


Awarded by NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Awarded by NATIONAL INSTITUTE ON AGING


Awarded by NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM


Funding Acknowledgements

This work was supported in part by a Consortium grant (U54 EB 020403) from the NIH Institutes contributing to the Big Data to Knowledge (BD2K) Initiative, including the NIBIB. Funding for individual consortium authors is listed in Hibar et al., Nature, 2015 and in other papers cited here. This paper was collaboratively written on Google Docs by all authors, over a period of several weeks. We thank Josh Faskowitz for making Fig. 3, the ENIGMA "roadmap".