Journal article
Childhood maltreatment modifies the relationship of depression with hippocampal volume
L Gerritsen, L Van Velzen, L Schmaal, Y Van Der Graaf, N Van Der Wee, MJ Van Tol, B Penninx, M Geerlings
Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2015
Abstract
Childhood maltreatment (CM) may modify the relationship between major depressive disorder (MDD) and hippocampal volume reduction. To disentangle the impact of MDD and CM on hippocampal volume we investigated the association between MDD and hippocampal volume in persons with and without a history of CM in two independent cohorts. Method. We used data of 262 participants from the Netherlands Study of Depression and Anxiety (NESDA) (mean age 37 years, 32% male) and 636 participants from the SMART-Medea study (mean age 61 years, 81% male). In both studies a 12-month diagnosis of MDD and CM were assessed using a diagnostic interview. Hippocampal volume was measured in NESDA using FreeSurfer softw..
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Awarded by Geestkracht program of the Netherlands Organization for Health Research and Development (Zon-Mw)
Awarded by Netherlands Organisation for Scientific Research VENI grant
Funding Acknowledgements
The infrastructure for the NESDA study (www.nesda.nl) is funded through the Geestkracht program of the Netherlands Organization for Health Research and Development (Zon-Mw, grant number 10-000-1002) and is supported by participating universities and mental health care organizations [VU University Medical Center, GGZ inGeest, Arkin, Leiden University Medical Center, GGZ Rivierduinen, University Medical Center Groningen, Lentis, GGZ Friesland, GGZ Drenthe, Institute for Quality of Health Care (IQ Healthcare), Netherlands Institute for Health Services Research (NIVEL) and Netherlands Institute of Mental Health and Addiction (Trimbos)]. L.G. is supported by a Netherlands Organisation for Scientific Research VENI grant (ZonMW 916-14-016).