Journal article
Effect of modafinil on impulsivity and relapse in alcohol dependent patients: A randomized, placebo-controlled trial
L Joos, AE Goudriaan, L Schmaal, E Fransen, W Van Den Brink, BGC Sabbe, G Dom
European Neuropsychopharmacology | ELSEVIER | Published : 2013
Abstract
Poor impulse control plays an important role in the development, course and relapse of substance use disorders. Therefore, improving impulse control may represent a promising approach in the treatment of alcohol dependence. This study aimed to test the effect of modafinil on impulse control and alcohol use in alcohol dependent patients (ADP) in a randomized, double-blind, placebo-controlled trial. Eighty-three abstinent ADP were randomized to 10 weeks modafinil (300. mg/d) or placebo. Alcohol use was quantified using the timeline follow-back method and was assessed until 6 months after treatment discontinuation. Impulsivity was assessed using self-report questionnaires (Barratt Impulsiveness..
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Funding Acknowledgements
Funding for this study was provided by the Netherlands Organization for Scientific Research, ZonMW (Grant 31160003). ZonMW had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit this paper for publication.