Journal article
The relationship between impulsive choice and impulsive action: A cross-species translational study
N Broos, L Schmaal, J Wiskerke, L Kostelijk, T Lam, N Stoop, L Weierink, J Ham, EJC de Geus, ANM Schoffelmeer, W van den Brink, DJ Veltman, TJ de Vries, T Pattij, AE Goudriaan
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Open access
Abstract
Maladaptive impulsivity is a core symptom in various psychiatric disorders. However, there is only limited evidence available on whether different measures of impulsivity represent largely unrelated aspects or a unitary construct. In a cross-species translational study, thirty rats were trained in impulsive choice (delayed reward task) and impulsive action (five-choice serial reaction time task) paradigms. The correlation between those measures was assessed during baseline performance and after pharmacological manipulations with the psychostimulant amphetamine and the norepinephrine reuptake inhibitor atomoxetine. In parallel, to validate the animal data, 101 human subjects performed analogo..
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Awarded by Netherlands Organization for Scientific Research (ZonMW)
Funding Acknowledgements
This study was financially supported by a grant from the Netherlands Organization for Scientific Research (ZonMW grant no. 3116003/www.ZonMW.nl). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.