Journal article

Anticoagulation Use and Clinical Outcomes Following Major Bleeding on Dabigatran or Warfarin in Atrial Fibrillation

I Hernandez, Y ZHANG, M Brooks, P Chin, S Saba

Stroke | Lippincott Williams & Wilkins Ltd. | Published : 2017

Abstract

Abstract Background and Purpose— Little is known about the clinical outcomes associated with posthemorrhage anticoagulation resumption for atrial fibrillation. This study had 2 objectives: first, to evaluate anticoagulation use after a first major bleed on warfarin or dabigatran and, second, to compare effectiveness and safety outcomes between patients discontinuing anticoagulation after a major bleed and patients restarting warfarin or dabigatran. Methods— Using 2010 to 2012 Medicare Part D data, we identified atrial fibrillation patients who experienced a major bleeding event while using warfarin (n=1135) or dabigatran (n=404) and categorized them by their posthemorrhage use of anticoagul..

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Grants

Awarded by Agency for Healthcare Research and Quality


Awarded by National Institute of Mental Health


Awarded by AGENCY FOR HEALTHCARE RESEARCH AND QUALITY


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

We acknowledge funding from Commonwealth Foundation and Agency for Healthcare Research and Quality (No R01 HS018657) and from the National Institute of Mental Health (No R21 MH100721). Hernandez has received a scholarship from "La Caixa" Foundation, Spain.