Journal article
An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers
G Bottai, C Raschioni, A Losurdo, L Di Tommaso, C Tinterri, R Torrisi, JS Reis-Filho, M Roncalli, C Sotiriou, A Santoro, A Mantovani, S Loi, L Santarpia
Breast Cancer Research | BMC | Published : 2016
Open access
Abstract
Background: Stromal tumor-infiltrating lymphocytes (TILs) are a robust prognostic factor in triple-negative breast cancer (TNBC). However, the clinical significance of TILs may be influenced by the complex landscape of the tumor immune microenvironment. In this study, we aimed to evaluate the composition and the functionality of lymphocytic infiltration and checkpoint receptors in TNBC. Methods: Formalin-fixed, paraffin-embedded tissues were retrospectively collected from a cohort of patients with early-stage TNBC treated with adjuvant anthracycline-based chemotherapy (n = 259). Results were validated in an independent cohort of patients with TNBC (n = 104). Stromal TILs were evaluated on he..
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Awarded by Find A Cure Today Breast Cancer Foundation
Funding Acknowledgements
This study was supported by a grant from Associazione Italiana Ricerca sul Cancro (AIRC Grant 6251 to L. Santarpia); and Fondazione Italiana Ricerca sul Cancro (FIRC fellowship 18328 to G. Bottai). The work of S. Loi is supported by the Cancer Council Victoria, the National Breast Cancer Foundation Australia, the Breast Cancer Foundation, NY, USA.