The contribution of Helicobacter pylori to excess gastric cancer in Indigenous and Pacific men: a birth cohort estimate

Abstract

Background: The reasons for higher gastric cancer incidence rates in indigenous populations are debated. Methods: We quantify the role of Helicobacter pylori in excess gastric cancer incidence in Māori and Pacific men in New Zealand. Age-standardized gastric cancer rate ratios for 1981–2004 were calculated in Māori and Pacific men compared with European/other men born in 1926–1940 and in 1941–1955. Rate ratios were then compared with those restricted to H. pylori prevalent populations. Results: H. pylori contributed substantially to excess gastric cancer incidence in Māori men (50%, 61%) and Pacific men (71%, 82%) in both cohorts. Conclusions: Policy should focus on reducing the acquisition ..