Journal article
Vitamin D insufficiency in the first 6 months of infancy and challenge-proven IgE-mediated food allergy at 1 year of age: a case-cohort study
J Molloy, JJ Koplin, KJ Allen, MLK Tang, F Collier, JB Carlin, R Saffery, D Burgner, S Ranganathan, T Dwyer, AC Ward, M Moreno-Betancur, M Clarke, AL Ponsonby, P Vuillermin
Allergy European Journal of Allergy and Clinical Immunology | WILEY | Published : 2017
DOI: 10.1111/all.13122
Abstract
Background: Ecological evidence suggests vitamin D insufficiency (VDI) due to lower ambient ultraviolet radiation (UVR) exposure may be a risk factor for IgE-mediated food allergy. However, there are no studies relating directly measured VDI during early infancy to subsequent challenge-proven food allergy. Objective: To prospectively investigate the association between VDI during infancy and challenge-proven food allergy at 1 year. Methods: In a birth cohort (n = 1074), we used a case-cohort design to compare 25-hydroxyvitamin D3 (25(OH)D3) levels among infants with food allergy vs a random subcohort (n = 274). The primary exposures were VDI (25(OH)D3 <50 nM) at birth and 6 months of age. Am..
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Funding Acknowledgements
The establishment work and infrastructure for the BIS was provided by the Murdoch Childrens Research Institute, Deakin University and Barwon Health. Subsequent funding was secured from the National Health and Medical Research Council of Australia, The Jack Brockhoff Foundation, the Scobie Trust, the Shane O'Brien Memorial Asthma Foundation, the Our Women's Our Children's Fund Raising Committee Barwon Health, The Shepherd Foundation, the Rotary Club of Geelong, the Ilhan Food Allergy Foundation and GMHBA. Support in kind has been provided by the Cotton on Foundation and CreativeForce. Vitamin D analysis for this work was performed by the CMCA (Metabolomics Australia) and was supported by infrastructure funding from the Western Australian State Government in partnership with Bioplatforms Australia and the Australian Federal Government, through the National Collaborative Research Infrastructure Strategy (NCRIS).