Journal article

Brain connectivity networks and longitudinal trajectories of depression symptoms in adolescence

Rachel Ellis, Marc L Seal, Christopher Adamson, Richard Beare, Julian G Simmons, Sarah Whittle, Nicholas B Allen



High levels of depression during adolescence may contribute to the risk for future depression later in life. This study examined the relationship between the developmental timing of depressive symptoms, and brain structural outcomes in late adolescence. In a prior work, we examined longitudinal trajectories of depressive symptoms in 243 adolescents (121 males and 122 females), and identified four subgroups: a normative group with stable low levels of depression, two groups with declining symptoms, and one group with increasing symptoms. For the current paper, diffusion-weighted MRI images were acquired at the final wave of the study, and used to perform white matter tractography and brain ne..

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Awarded by National Health and Medical Research Council (NHMRC; Australia)

Awarded by Australian Research Council (ARC)

Awarded by NHMRC Career Development Fellowship

Funding Acknowledgements

This research was conducted within the Developmental Imaging research group, Murdoch Childrens Research Institute and the Children's MRI Centre, Royal Children's Hospital, Melbourne, Victoria. It was supported by the Murdoch Childrens Research Institute, the Royal Children's Hospital Foundation, the Department of Paediatrics at The University of Melbourne, and the Victorian Government's Operational Infrastructure Support Program. This research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Australia; Program Grant 350241), and the Australian Research Council (ARC; Discovery Grants DP0878136 & DP1092637). Dr. Whittle is supported by an NHMRC Career Development Fellowship (ID: 1007716). Dr. Ellis was supported by an Australian Postgraduate Award. The funding sources had no role in the planning of this research or the preparation of this article.