Journal article

The role of MDM2 and MDM4 in breast cancer development and prevention

Sue Haupt, Reshma Vijayakumaran, Panimaya Jeffreena Miranda, Andrew Burgess, Elgene Lim, Ygal Haupt

JOURNAL OF MOLECULAR CELL BIOLOGY | OXFORD UNIV PRESS | Published : 2017

Abstract

The major cause of death from breast cancer is not the primary tumour, but relapsing, drug-resistant, metastatic disease. Identifying factors that contribute to aggressive cancer offers important leads for therapy. Inherent defence against carcinogens depends on the individual molecular make-up of each person. Important molecular determinants of these responses are under the control of the mouse double minute (MDM) family: comprised of the proteins MDM2 and MDM4. In normal, healthy adult cells, the MDM family functions to critically regulate measured, cellular responses to stress and subsequent recovery. Proper function of the MDM family is vital for normal breast development, but also for p..

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Grants

Awarded by NHMRC project


Awarded by NBCF


Awarded by CCV


Awarded by NBCF practitioner fellowship


Awarded by National Health and Medical Research Council of Australia


Awarded by National Breast Cancer Foundation


Funding Acknowledgements

The work in the Haupt laboratory is supported by NHMRC project grants (1123057 and 1063389), an innovator grant from NBCF (IN-16-042), and by a grant from CCV (1085154). E.L. is supported through Love Your Sister and an NBCF practitioner fellowship (PRAC14-02).