Journal article

Breast milk polyunsaturated fatty acids: associations with adolescent allergic disease and lung function

NT Waidyatillake, R Stoney, F Thien, CJ Lodge, JA Simpson, KJ Allen, MJ Abramson, B Erbas, C Svanes, SC Dharmage, AJ Lowe

ALLERGY | WILEY | Published : 2017


BACKGROUND: It has been hypothesized that n-3 PUFA in breast milk may assist immune and lung development. There are very limited data on possible long-term effects on allergic disease and lung function. The aim was to investigate associations of n-3 and n-6 PUFA levels in colostrum and breast milk with allergic disease and lung function at ages 12 and 18 years. METHODS: Polyunsaturated fatty acids were measured in 194 colostrum samples and in 118 three-month expressed breast milk samples from mothers of children enrolled in the Melbourne Atopy Cohort (MACS) Study, a high-risk birth cohort study. Associations with allergic diseases, skin prick tests and lung function assessed at 12 and 18 yea..

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Awarded by NHMRC Australia

Funding Acknowledgements

NW was supported by the Melbourne International Research Scholarship (MIRS) to undertake this work. The National Health and Medical Research Council of Australia (NHMRC) provided support for S.C.D, C.J.L, M.C.M and A.J.L, and Charles and Sylvia Viertel Medical Research Foundation supported K.J.A.Nestec Ltd, a subsidiary of Nestle Australia, provided the study formula and staff funding during the first 6 years of the study. The 12-year follow-up was supported by the Asthma Foundation of Victoria, while the 18-year follow-up by the NHMRC Australia (APP454856).