Journal article
Effects of Plasmodium falciparum infection on umbilical artery resistance and intrafetal blood flow distribution: A Doppler ultrasound study from Papua New Guinea NCT01136850 NCT
M Ome-Kaius, S Karl, RA Wangnapi, JW Bolnga, G Mola, J Walker, I Mueller, HW Unger, SJ Rogerson
Malaria Journal | BMC | Published : 2017
Abstract
Background: Doppler velocimetry studies of umbilical artery (UA) and middle cerebral artery (MCA) flow help to determine the presence and severity of fetal growth restriction. Increased UA resistance and reduced MCA pulsatility may indicate increased placental resistance and intrafetal blood flow redistribution. Malaria causes low birth weight and fetal growth restriction, but few studies have assessed its effects on uteroplacental and fetoplacental blood flow. Methods: Colour-pulsed Doppler ultrasound was used to assess UA and MCA flow in 396 Papua New Guinean singleton fetuses. Abnormal flow was defined as an UA resistance index above the 90th centile, and/or a MCA pulsatility index and ce..
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Grants
Awarded by Bill and Melinda Gates Foundation
Funding Acknowledgements
This research was supported by the Malaria in Pregnancy Consortium, through a grant from the Bill & Melinda Gates Foundation (46099); Pfizer Inc (investigator-initiated research grant WS394663), a PNGIMR Internal Competitive Research Award to MO, and the Pregvax Consortium, through a grant from the European Union's Seventh Framework Programme FP7-2007-HEALTH (PREGVAX 201588). SK received a National Health and Medical Research Council (NHMRC) Early Career Fellowship (#1052960), and IM received an NHMRC Senior Research Fellowship (#1043345). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.