Journal article
Review article: The practical management of acute severe ulcerative colitis
D Seah, P De Cruz
Alimentary Pharmacology and Therapeutics | WILEY | Published : 2016
DOI: 10.1111/apt.13491
Abstract
Background Acute severe ulcerative colitis (ASUC) is a life-threatening condition for which optimal management strategies remain ill-defined. Aim To review the evidence regarding the natural history, diagnosis, monitoring and treatment of ASUC to inform an evidence-based approach to management. Methods Relevant articles addressing the management of ASUC were identified from a search of MEDLINE, the Cochrane Library and conference proceedings. Results Of ASUC, 31-35% is steroid-refractory. Infliximab and ciclosporin salvage therapies have improved patient outcomes in randomised controlled trials. Short-term response rates (within 3 months) have ranged from 40% - 54% for ciclosporin and 46-83%..
View full abstractGrants
Funding Acknowledgements
PDC has received educational support, consulted on advisory boards and been a speaker at educational symposia sponsored by Shire, Ferring, Janssen and AbbVie. Peter De Cruz is supported by a GESA Bushell Postdoctoral Fellowship and David Bickart Clinician Research Fellowship from the University of Melbourne.