Journal article
Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target
A Straub, S Krajewski, JD Hohmann, E Westein, F Jia, N Bassler, C Selan, J Kurz, HP Wendel, S Dezfouli, Y Yuan, H Nandurkar, S Jackson, MJ Hickey, K Peter
Arteriosclerosis Thrombosis and Vascular Biology | LIPPINCOTT WILLIAMS & WILKINS | Published : 2011
Abstract
Objective-: Hypothermia is used in various clinical settings to inhibit ischemia-related organ damage. However, prothrombotic effects have been described as potential side effects. This study aimed to elucidate the mechanism of hypothermia-induced platelet activation and subsequent prothrombotic events and to develop preventative pharmacological strategies applicable during clinically used hypothermia. Methods and Results-: Platelet function was investigated ex vivo and in vivo at clinically used hypothermia (28°C/18°C). Hypothermic mice demonstrated increased expression of platelet activation marker P-selectin, platelet-leukocyte aggregate formation, and thrombocytopenia. Intravital microsc..
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Awarded by German Research Foundation
Funding Acknowledgements
Dr Straub was supported by a grant from the German Research Foundation (STR 687/1-1); Dr Peter was supported by the Australian Research Council; and Drs Bassler, Jackson, Hickey, and Peter were supported by the National Health and Medical Research Council of Australia.