Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic development
Neil I Bower, Adam J Vogrin, Ludovic Le Guen, Huijun Chen, Steven A Stacker, Marc G Achen, Benjamin M Hogan
DEVELOPMENT | COMPANY BIOLOGISTS LTD | Published : 2017
Vascular endothelial growth factors (VEGFs) control angiogenesis and lymphangiogenesis during development and in pathological conditions. In the zebrafish trunk, Vegfa controls the formation of intersegmental arteries by primary angiogenesis and Vegfc is essential for secondary angiogenesis, giving rise to veins and lymphatics. Vegfd has been largely thought of as dispensable for vascular development in vertebrates. Here, we generated a zebrafish vegfd mutant by genome editing. vegfd mutants display significant defects in facial lymphangiogenesis independent of vegfc function. Strikingly, we find that vegfc and vegfd cooperatively control lymphangiogenesis throughout the embryo, including du..View full abstract
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Awarded by National Health and Medical Research Council/National Heart Foundation of Australia Career Development Fellowship
Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia and by a Senior Research Fellowship (1050138, 1053535 and 1042460 to S.A.S.). B.M.H. was supported by a co-funded National Health and Medical Research Council/National Heart Foundation of Australia Career Development Fellowship (100442, 1083811).