The Role of the Tumor vasculature in the Host immune Response: implications for Therapeutic Strategies Targeting the Tumor Microenvironment
Shona A Hendry, Rae H Farnsworth, Benjamin Solomon, Marc G Achen, Steven A Stacker, Stephen B Fox
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2016
Recently developed cancer immunotherapy approaches including immune checkpoint inhibitors and chimeric antigen receptor T cell transfer are showing promising results both in trials and in clinical practice. These approaches reflect increasing recognition of the crucial role of the tumor microenvironment in cancer development and progression. Cancer cells do not act alone, but develop a complex relationship with the environment in which they reside. The host immune response to tumors is critical to the success of immunotherapy; however, the determinants of this response are incompletely understood. The immune cell infiltrate in tumors varies widely in density, composition, and clinical signif..View full abstract
Related Projects (2)
Awarded by National Health and Medical Research Council of Australia
The work is supported by a Program Grant (1053535) from the National Health and Medical Research Council of Australia. SS is supported by Research Fellowship (1060498) from the National Health and Medical Research Council of Australia.