Reduced Cortical Volume and Elevated Astrocyte Density in Rats Chronically Treated With Antipsychotic Drugs-Linking Magnetic Resonance Imaging Findings to Cellular Pathology
Anthony C Vernon, William R Crum, Jason P Lerch, Winfred Chege, Sridhar Natesan, Michel Modo, Jonathan D Cooper, Steven CR Williams, Shitij Kapur
Biological Psychiatry | ELSEVIER SCIENCE INC | Published : 2014
Awarded by Medical Research Council
Awarded by EPSRC
Strategic funding from the Medical Research Council (Grant ID: G0701748  and G1002198), whom we thank for their generous financial assistance, supported this study. We also thank the British Heart Foundation for supporting the 7T MRI scanner at the Kings College London Preclinical imaging unit (KCLPIU) and acknowledge the technical support of Dr. Po-Wah So (KCLPIU). JDC acknowledges support from the Batten Disease Support and Research Association, Batten Disease Family Association, and The Natalie Fund that provided the microscope set-up. SCRW and WRC acknowledge support from the National Institute for Health Research Biomedical Research Centre for Mental Health at the South London and Maudsley National Health Service Foundation Trust and Institute of Psychiatry, Kings College London, and the King's College London Centre of Excellence in Medical Engineering funded by the Wellcome Trust and EPSRC (WT 088641/Z/09/Z).ACV, WRC, JPL, WC, SN, MM, JDC, and SCRW report no biomedical financial interests or potential conflicts of interest. Although we do not deem there to be any conflicting interest, we declare to the editor and readers that SK has received grant support from AstraZeneca and GlaxoSmithKline and has served as consultant and/or speaker for AstraZeneca, Bioline, BMS-Otsuka, Eli Lilly, Janssen (Johnson and Johnson), Lundbeck, NeuroSearch, Pfizer, Roche, Servier, and Solvay Wyeth in the last 3 years.