Stroke Treatment Academic Industry Roundtable Recommendations for Individual Data Pooling Analyses in Stroke.
Kennedy R Lees, Pooja Khatri, undefined STAIR IX Collaborators
Stroke | Published : 2016
Pooled analysis of individual patient data from stroke trials can deliver more precise estimates of treatment effect, enhance power to examine prespecified subgroups, and facilitate exploration of treatment-modifying influences. Analysis plans should be declared, and preferably published, before trial results are known. For pooling trials that used diverse analytic approaches, an ordinal analysis is favored, with justification for considering deaths and severe disability jointly. Because trial pooling is an incremental process, analyses should follow a sequential approach, with statistical adjustment for iterations. Updated analyses should be published when revised conclusions have a clinica..View full abstract