Journal article

Neurite density index is sensitive to age related differences in the developing brain

Sila Genc, Charles B Malpas, Scott K Holland, Richard Beare, Timothy J Silk



PURPOSE: White matter development during childhood and adolescence is characterised by increasing white matter coherence and organisation. Commonly used scalar metrics, such as fractional anisotropy (FA), are sensitive to multiple mechanisms of white matter change and therefore unable to distinguish between mechanisms that change during development. We investigate the relationship between age and neurite density index (NDI) from neurite orientation dispersion and density imaging (NODDI), and the age-classification accuracy of NDI compared with FA, in a developmental cohort. METHOD: Diffusion-weighted imaging data from 72 children and adolescents between the ages of 4-19 was collected (M=10.4..

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Awarded by National Institute of Child Health and Human Development

Funding Acknowledgements

Data used in the preparation of this article were obtained from the Cincinnati MR Imaging of NeuroDevelopment (C-MIND) Data Repository created by the C -MIND study of Normal Brain Development. This is a multisite, longitudinal study of typically developing children aged from newborn through to young adulthood conducted by Cincinnati Children's Hospital Medical Center and UCLA and supported by the National Institute of Child Health and Human Development (Contract #s HHSN275200900018C). A listing of the participating sites and a complete listing of the study investigators can be found at This manuscript reflects the views of the authors and may not reflect the opinions or views of the NIH. The analysis was conducted within the Developmental Imaging research group, Murdoch Childrens Research Institute (MCRI), supported by The Royal Children's Hospital Foundation and the Victorian Government's Operational Infrastructure Support Program.