Relaxin-3 Inputs Target Hippocampal Interneurons and Deletion of Hilar Relaxin-3 Receptors in "Floxed-RXFP3" Mice Impairs Spatial Memory
M Haidar, G Guevremont, C Zhang, RAD Bathgate, E Timofeeva, CM Smith, AL Gundlach
HIPPOCAMPUS | WILEY | Published : 2017
Hippocampus is innervated by γ-aminobutyric acid (GABA) "projection" neurons of the nucleus incertus (NI), including a population expressing the neuropeptide, relaxin-3 (RLN3). In studies aimed at gaining an understanding of the role of RLN3 signaling in hippocampus via its Gi/o -protein-coupled receptor, RXFP3, we examined the distribution of RLN3-immunoreactive nerve fibres and RXFP3 mRNA-positive neurons in relation to hippocampal GABA neuron populations. RLN3-positive elements were detected in close-apposition with a substantial population of somatostatin (SST)- and GABA-immunoreactive neurons, and a smaller population of parvalbumin- and calretinin-immunoreactive neurons in different hi..View full abstract
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Awarded by National Health and Medical Research Council of Australia
Grant sponsor: National Health and Medical Research Council of Australia; Grant numbers: 1024885, 1067522; Grant sponsors: Brain & Behavior Research Foundation (USA) NARSAD Independent Investigator Award; Victorian Government Operational Infrastructure Support Programme; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alzheimer's Australia Dementia Research Foundation, Postgraduate Scholarship; Bethlehem Griffiths Research Foundation, Postgraduate Scholarship.