Infection Programs Sustained Lymphoid Stromal Cell Responses and Shapes Lymph Node Remodeling upon Secondary Challenge
Julia L Gregory, Anne Walter, Yannick O Alexandre, Jyh Liang Hor, Ruijie Liu, Joel Z Ma, Sapna Devi, Nobuko Tokuda, Yuji Owada, Laura K Mackay, Gordon K Smyth, William R Heath, Scott N Mueller
Cell Reports | CELL PRESS | Published : 2017
Lymph nodes (LNs) are constructed of intricate networks of endothelial and mesenchymal stromal cells. How these lymphoid stromal cells (LSCs) regulate lymphoid tissue remodeling and contribute to immune responses remains poorly understood. We performed a comprehensive functional and transcriptional analysis of LSC responses to skin viral infection and found that LSC subsets responded robustly, with different kinetics for distinct pathogens. Recruitment of cells to inflamed LNs induced LSC expansion, while B cells sustained stromal responses in an antigen-independent manner. Infection induced rapid transcriptional responses in LSCs. This transcriptional program was transient, returning to hom..View full abstract
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Awarded by Australian Research Council
We thank Rafi Ahmed (Emory University, GA) for LCMV virus, Weisan Chen (La Trobe University) for vaccinia virus (which was originally a gift from Jonathan Yewdell and Jack Bennink [NIH, Bethesda, MD]), Michael Hickey (Monash University) for PS/2 and M17/4 antibodies, and Hidde Ploegh (Whitehead Institute, Cambridge, MA) for OBI mice. This work was supported by the Australian Research Council (DP140101246).