Novel genetic loci associated with hippocampal volume

DP Hibar; HHH Adams; N Jahanshad; G Chauhan; JL Stein; E Hofer; ME Renteria; JC Bis; A Arias-Vasquez; MK Ikram; S Desrivières; MW Vernooij; L Abramovic; S Alhusaini; N Amin; M Andersson; K Arfanakis; BS Aribisala; NJ Armstrong; L Athanasiu; T Axelsson; AH Beecham; A Beiser; M Bernard; SH Blanton; MM Bohlken; MP Boks; J Bralten; AM Brickman; O Carmichael; MM Chakravarty; Q Chen; CRK Ching; V Chouraki; G Cuellar-Partida; F Crivello; A Den Braber; NT Doan; S Ehrlich; S Giddaluru; AL Goldman; RF Gottesman; O Grimm; ME Griswold; T Guadalupe; BA Gutman; J Hass; UK Haukvik; D Hoehn; AJ Holmes; M Hoogman; D Janowitz; T Jia; KN Jørgensen; N Karbalai; D Kasperaviciute; S Kim; M Klein; B Kraemer; PH Lee; DCM Liewald; LM Lopez; M Luciano; C MacAre; AF Marquand; M Matarin; KA Mather; M Mattheisen; DR McKay; Y Milaneschi; S Muñoz Maniega; K Nho; AC Nugent; P Nyquist; LMO Loohuis; J Oosterlaan; M Papmeyer; L Pirpamer; B Pütz; A Ramasamy; JS Richards; SL Risacher; R Roiz-Santiañez; N Rommelse; S Ropele; EJ Rose; NA Royle; T Rundek; PG Sämann; A Saremi; CL Satizabal; L Schmaal; AJ Schork; L Shen; J Shin; E Shumskaya; AV Smith; E Sprooten; LT Strike; A Teumer

Journal article

Novel genetic loci associated with hippocampal volume

DP Hibar, HHH Adams, N Jahanshad, G Chauhan, JL Stein, E Hofer, ME Renteria, JC Bis, A Arias-Vasquez, MK Ikram, S Desrivières, MW Vernooij, L Abramovic, S Alhusaini, N Amin, M Andersson, K Arfanakis, BS Aribisala, NJ Armstrong, L Athanasiu Show all

Nature Communications | Published : 2017

DOI: 10.1038/ncomms13624

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Abstract

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a..

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