Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
Renea A Taylor, Michael Fraser, Julie Livingstone, Shadrielle Melijah G Espiritu, Heather Thorne, Vincent Huang, Winnie Lo, Yu-Jia Shiah, Takafumi N Yamaguchi, Ania Sliwinski, Sheri Horsburgh, Alice Meng, Lawrence E Heisler, Nancy Yu, Fouad Yousif, Melissa Papargiris, Mitchell G Lawrence, Lee Timms, Declan G Murphy, Mark Frydenberg Show all
Nature Communications | NATURE PUBLISHING GROUP | Published : 2017
Awarded by Movember Foundation
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC
Awarded by National Breast Cancer Foundation
The authors thank all members of the Boutros, Risbridger and Bristow labs for helpful suggestions, and Eveline Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics, and the many families who contribute to kConFab. The results described here are in part based upon data generated by the TCGA Research Network: http://cancergenome.nih.gov/. This study was conducted with the support of Movember funds through Prostate Cancer Canada and with the additional support of the Ontario Institute for Cancer Research, funded by the Government of Ontario. This study was conducted with the support of the Ontario Institute for Cancer Research to PCB through funding provided by the Government of Ontario. This work was supported by Prostate Cancer Canada and is proudly funded by the Movember Foundation-Grant #RS2014-01 to PCB. PCB was supported by a Terry Fox Research Institute New Investigator Award and a CIHR New Investigator Award. This project was supported by Genome Canada through a Large-Scale Applied Project contract to PCB and Drs. Ryan Morin and Sohrab P. Shah. The authors gratefully thank the Princess Margaret Cancer Centre Foundation and Radiation Medicine Program Academic Enrichment Fund for support (to R.G.B.). R.G.B. is a recipient of a Canadian Cancer Society Research Scientist Award. This study was supported with funds from National Health and Medical Research Council of Australia (NHMRC ID APP1077799), Victorian State Government Cancer Agency Program Grant (Prostate Translational Research in Victoria Collaboration; CAPTIV) and TissuPath. R.A.T. was supported by Victorian Cancer Agency Fellowship. G.P.R. was supported by NHMRC Fellowships (IDs: 1002648 & 1102752). MGL was supported by a NHMRC Fellowship (1035721) and Movember Young Investigator Grant from the Prostate Cancer Foundation of Australia. kConFab is supported by a grant from the National Breast Cancer Foundation, and previously by the National Health and Medical Research Council, the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia and the Cancer Foundation of Western Australia.