Journal article
Development of an Australian cardiovascular disease mortality risk score using multiple imputation and recalibration from national statistics
Kathryn Backholer, Yoichiro Hirakawa, Andrew Tonkin, Graham Giles, Dianna J Magliano, Stephen Colagiuri, Mark Harris, Paul Mitchell, Mark Nelson, Jonathan E Shaw, David Simmons, Leon Simons, Anne Taylor, Jessica Harding, Bamini Gopinath, Mark Woodward
BMC CARDIOVASCULAR DISORDERS | BIOMED CENTRAL LTD | Published : 2017
Abstract
OBJECTIVE: To develop and recalibrate an Australian 5-year cardiovascular disease (CVD) mortality risk score to produce contemporary predictions of risk. METHODS: Data were pooled from six Australian cohort studies (n = 54,829), with baseline data collected between 1989 and 2003. Participants included were aged 40-74 years and free of CVD at baseline. Variables were harmonised across studies and missing data were imputed using multiple imputation. Cox proportional hazards models were used to estimate the risk of CVD mortality associated with factors mutually independently predictive (p < 0.05) and a 5-year risk prediction algorithm was constructed. This algorithm was recalibrated to reflect ..
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Grants
Awarded by Australian National Heart Foundation
Awarded by National Heart Foundation of Australia Post-Doctoral Fellowship
Awarded by National Health and Medical Research Council
Awarded by Australian NHMRC
Funding Acknowledgements
This work was funded by a grant (100751) from the Australian National Heart Foundation. Kathryn Backholer was supported by a National Heart Foundation of Australia Post-Doctoral Fellowship (PH 12 M6824) and Mark Woodward was supported by a National Health and Medical Research Council Principal Research Fellowship.Data from five studies - The Australian, Diabetes Obesity and Lifestyle Study, Blue Mountain Eyes Study, The Dubbo study, The Crossroads Undiagnosed Diabetes Study and the North West Adelaide Health Study - were obtained from The Australian and New Zealand Diabetes and Cancer Cohort. This was funded by a National Health and Medical Research Council grant (APP1002663).Baseline recruitment for the Melbourne Collaborative Cohort Study was funded by VicHealth and Cancer Council Victoria. Follow-up has been supported by Australian NHMRC grants 209057, 251553 and 504711 and by infrastructure provided by Cancer Council Victoria. Deaths have been ascertained through the Victorian Registrar of Births Deaths and Marriages and by record linkage to the National Death Index at the Australian Institute of Health and Welfare. Australian national data were obtained from the Australian Bureau of Statistics.