Journal article

Astrocytes: Adhesion Molecules and Immunomodulation

Shane Liddelow, Daniel Hoyer

Current Drug Targets | BENTHAM SCIENCE PUBL LTD | Published : 2016

Abstract

Protection of neurons, as well as maintenance of their general homeostasis and trophic support is performed by glial cells. Astrocytes, the most abundant glial cell, increase in size and number evolutionarily such that invertebrates contain fewer small astrocytes, while humans have large multi-branched astrocytes that constitute up to 60% of central nervous system (CNS) cells. Astrocytes provide neurotrophic support, induce synaptogenesis and are integral for maintenance and pruning of synapses in the adult. Following injury and in disease, their ability to respond to, and initiate initial responses to injury/disease is increasingly apparent - with alterations in function that disrupt the in..

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