Journal article

Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis

KA Browne, RW Johnstone, DA Jans, JA Trapani

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2000

DOI: 10.1074/jbc.C000622200

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Keywords

Family
Contractile Proteins
Abp-280
Dose-Response Relationship, Drug
Precipitin Tests
Two-Hybrid System Techniques
Cytosolic Delivery
Gelsolin
Dna Fragmentation
Staurosporine
Granzymes
Gene
Binding Sites
Caspases
Humans
Pore Forming Cytotoxic Proteins
Cell Survival
Microfilament Proteins
Antigens, Cd95
Life Sciences & Biomedicine
Apoptosis
Target-Cells
Chromium Radioisotopes
Biochemistry & Molecular Biology
Perforin
T-Lymphocytes, Cytotoxic
Mediated Apoptosis
Filamins
Ligands
Membrane Glycoproteins
Cytoplasm
Fas Receptor
Cysteine Proteinase Inhibitors
Serine Endopeptidases
Cell Nucleus
Jurkat Cells
Amino Acid Chloromethyl Ketones
Science & Technology
Enzyme Inhibitors
Cell Membrane
Tumor Cells, Cultured
in Situ Nick-End Labeling
Dependence