Journal article

Filamin (280-kDa actin-binding protein) is a caspase substrate and is also cleaved directly by the cytotoxic T lymphocyte protease granzyme B during apoptosis

KA Browne, RW Johnstone, DA Jans, JA Trapani

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2000

DOI: 10.1074/jbc.C000622200

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Keywords

Perforin
Ligands
Serine Endopeptidases
Family
Cytosolic Delivery
Contractile Proteins
Two-Hybrid System Techniques
Dependence
Cytoplasm
Binding Sites
Dose-Response Relationship, Drug
Gelsolin
Jurkat Cells
Science & Technology
Cell Membrane
Caspases
Cysteine Proteinase Inhibitors
Tumor Cells, Cultured
Fas Receptor
Biochemistry & Molecular Biology
Gene
Life Sciences & Biomedicine
Cell Survival
Membrane Glycoproteins
Precipitin Tests
Abp-280
Enzyme Inhibitors
Chromium Radioisotopes
Pore Forming Cytotoxic Proteins
T-Lymphocytes, Cytotoxic
Staurosporine
Mediated Apoptosis
Target-Cells
Amino Acid Chloromethyl Ketones
Apoptosis
Dna Fragmentation
Cell Nucleus
Humans
Granzymes
Microfilament Proteins
in Situ Nick-End Labeling
Filamins