Human Inositol Polyphosphate Multikinase Regulates Transcript-Selective Nuclear mRNA Export to Preserve Genome Integrity
Vihandha O Wickramasinghe, Jane M Savill, Sreenivas Chavali, Asta B Jonsdottir, Eeson Rajendra, Tamara Gruener, Ronald A Laskey, M Madan Babu, Ashok R Venkitaraman
Molecular Cell | CELL PRESS | Published : 2013
Awarded by HFSP
Awarded by Medical Research Council
We thank Prof. Robin Irvine (University of Cambridge) and members of the Venkitaraman laboratory for helpful discussions and Anand Jeyasekharan for technical assistance. J.M.S. was supported by a UK Medical Research Council (MRC) studentship to A. R. V. This work was supported by the Medical Research Council (S. C. and M. M. B.), HFSP (RGY0073/2010, M. M. B.), EMBO (Young Investigator Program, M. M. B.; Long-Term Fellowship, S. C.), and ERASysBio+ (GRAPPLE, S. C. and M. M. B.). This work was also supported by grants to A. R. V. from the European Union (FP7 TRIREME, supporting A.B.J. and T. G.) and the MRC (supporting V.O.W. and E. R.). V.O.W., J.M.S., A.B.J., T. G., and A. R. V. conceived of and performed the experiments reported in this paper. E. R. performed structural analyses of IPMK and homologous proteins to identify mutations impairing catalysis. S. C. and M. M. B. performed statistical analyses of mRNA motifs. A. R. V. wrote the paper, with assistance from V.O.W. and J.M.S.