Journal article
Large-Scale Phylogenomic Analysis Reveals the Complex Evolutionary History of Rabies Virus in Multiple Carnivore Hosts
C Troupin, L Dacheux, M Tanguy, C Sabeta, H Blanc, C Bouchier, M Vignuzzi, S Duchene, EC Holmes, H Bourhy
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
The natural evolution of rabies virus (RABV) provides a potent example of multiple host shifts and an important opportunity to determine the mechanisms that underpin viral emergence. Using 321 genome sequences spanning an unprecedented diversity of RABV, we compared evolutionary rates and selection pressures in viruses sampled from multiple primary host shifts that occurred on various continents. Two major phylogenetic groups, bat-related RABV and dog-related RABV, experiencing markedly different evolutionary dynamics were identified. While no correlation between time and genetic divergence was found in bat-related RABV, the evolution of dog-related RABV followed a generally clock-like struc..
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Awarded by Horizon 2020 Framework Programme
Funding Acknowledgements
This work was supported by European Union Seventh Framework Programme PREDEMICS (grant number 278433) and by the Agence Nationale de la Recherche (grant number BSV3-0019). The Genomics Platform is member of "France Genomique" consortium (ANR10-INBS-09-08). SD is supported by a University of Melbourne McKenzie fellowship. ECH is supported by an NHMRC Australia Fellowship. HB and CS were supported by the European Virus Archive goes Global (EVAg) project that has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 653316. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.